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Irritation fibroma, also known as traumatic fibroma or focal fibrous hyperplasia, is the most common soft tissue exophytic lesion occurring in the oral cavity. It is a reactive lesion, caused mostly by chronic trauma to the oral mucous membranes. There is no gender or racial predilection, and the most common sites for irritation fibromas are the buccal and labial mucosa and the lateral surface of the tongue. Typical lesion presents as smooth, dome-shaped or pedunculated nodule with color of surrounding mucosa. Histopathologically, irritation fibromas are characterized by their dome shape with a keratinized stratified squamous epithelium, dense bundles of collagen fibers, spindle- or fibroblast-like cells, relatively few blood vessels and inflammatory cells in the submucosa. Although dermatologist should have interest in irritation fibromas due to their higher prevalence, there have been few reports in dermatologic literatures. Herein, we report two cases of multiple irritation fibromas on the lower lip, following lip biting.
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